The Hebrew University of Jerusalem leading the way in Nanotechnology specifically in Technology Transfer Services
By bluepanjeet on Apr 24, 2008 in *Ideas Meets Improvements
For years we have already heard the term Nanotechnology or Nanoscience. Even in the movie Spiderman 2, Peter Parker mentioned it as his field of interest while talking to the Nanoscientist Dr. Otto Octavius. But what is Nanotechnology? Nanotechnology is a technology that creates small materials at the scale of molecules by manipulating single atoms. The name “nano” comes from the size of molecules which is measured in nanometers - or one billionth of a meter (0.000000001 meter). The dimension of single atoms is ten fold smaller. But the works of Dr. Otto Octavius is not all fictional since there are real-life institutions that actually use this technology to improve the lives of many. One such institution is the Hebrew University of Jerusalem, or better known as the Technology Transfer University in which world-renowned researchers, world-class facilities, and the close cooperation with Israel’s leading pharmaceutical companies and hospitals gives the university an edge in the development of innovative drug delivery solutions.
Novel drug delivery solutions started because of a wide summation of research results into many different Technology Transfer Services areas and fields, including polymers, liposomes, microparticulate and nanoparticulate targeting systems, and controlled release and encapsulation technologies. At the Hebrew University, developments and research of drug release and delivery system is already in progress by some of the world’s best scientists in various fields of nanotechnology:
- In the College of Pharmacy for example, Professor Simon Benita specializes in microparticulate and nanoparticulate targetable drug delivery systems. On the other hand, Professor Abraham Domb’ expertise in degradable polymers, nanoparticles, and biomaterials is outstanding. While Professor Elka Touitou is a lead researcher for the enhanced delivery of peptides and other drugs that specifically passes through biological membranes.
- At the Casali Institute of Applied Chemistry however, Professor Shlomo Magdassi has an expertise in the dispersion systems, formulation chemistry, surfactants, microparticles, nanotechnology and microcapsules.
- While in the Department of Organic Chemistry Professor Chaim Gilon achieved specialization in medicinal chemistry and synthetic chemistry.
- The Institutes of Biochemistry, Food Science and Nutrition of the Faculty of Agricultural, Food and Environmental Quality Sciences is proud of Professor Amos Nussinovitch who is an expert in the theoretical and practical aspects of hydrocolloids, which includes hydrocolloid glues, water-soluble polymer uses, coating of cells and hydrocolloid cellular solids.
There are numerous achievements that the Hebrew University has been proud of because of several significant successes in this truly cutting-edge field like:
- The Doxil (Doxorubicin HCI liposome injection) which is Alza’s lead product for oncology, and was developed by Professor Yechezkel Barenholz of the Faculty of Medicine. It resulted in $375 million in sales in 2006.
- NasVax Ltd however was co-founded by Professor Barenholz in order to develop intranasal delivery systems based on platform technology which was further developed together with Professor Eli Kedar of the Hadassah Medical School. The intranasal delivery system of the company for the influenza vaccine came about starting from bench to clinical trials in less than 18 months. Within a year of business, NasVax completed two private investment rounds and had a successful IPO on the Tel Aviv Stock Exchange (TASE). The company is traded under the symbol NSVX.
- And Novagali Ltd. was established in order to develop solutions for ophthalmology. Based on technology expanded by Professor Simon Benita, Novagali’s channel includes major products at various stages of development for dry eye, allergy, glaucoma, retinopathies, and more. To date, Novagali has succeeded in raising €44 million in investment funding.
There are also outstanding new technologies at the Hebrew University, among the drug delivery technologies, Yissum has availability for Technology Transfer Opportunities and commercialization like:
- A process for setting up a non-toxic, biodegradable polymers that can be designed to exhibit pre-determined characteristics and functionality
- A new combination of FDA-approved drugs for intranasal drug delivery
- An antioxidants’ sustained release delivery system
- A transdermal and topical drug delivery through Highly adhesive patches which are derived from a tree gum exudate
- A method for loading liposomes with biologically active material by way of simple and flexible encapsulation process
The Hebrew University Center for Nanoscience and Nanotechnology which is Yissum is continuing it’s commitment to humanity by making drug delivery system attainable and beneficial to science, medicine and mankind.
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